Cancer treatment has been a major focus of research due to the various treatment options available and the severe side effects of medications. In recent years, nanotechnology has become a fascinating area of study for using nanoparticles (NPs) to deliver medicine for cancer treatment and diagnosis, as well as tissue repair. Poly lactic-co-glycolic acid (PLGA) NPs are a promising option due to their adaptability, biodegradability, and biocompatibility. They can be used in drug delivery systems for medical therapies, including targeted medicine distribution for cancer treatment. However, the particle size, surface charge, and other physicochemical properties of NPs must be carefully controlled to ensure desired pharmacological activity, drug release profile, and target selectivity. Changing one property may affect others and altering the ratio of single units (monomers) in the polymers may impact hydrophobicity and crystallinity. Designing optimal NPs is like solving a complex Rubik’s cube, where each side is interconnected, and changing one aspect affects the overall outcome.

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