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  Scopus ID: 21100926589

Iron Oxide Nanoparticles Synthesized Using Mentha piperita Extract and Evaluation of Its Antibacterial and Antimigratory Potential on Highly Metastatic Human Breast Cells

Huzaifa Umar, Maryam Rabiu Aliyu and Dilber Uzun Ozsahin
 

Abstract

Iron oxide nanoparticles (Fe2O3 NPs) stabilized with Mentha piperita obtained from Cyprus were synthesized. The study focused on exploring the anti-migratory potential, cytotoxicity, anti-proliferative and antimicrobial potential of Fe2O3 NPs using wound healing assay, trypan blue, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and disc diffusion, respectively. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Ultraviolet-Visible spectroscopy (UV-vis), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) were used to characterize the Fe2O3 NPs. The spectra obtained from FTIR, XRD, and SEM-EDX confirmed the formation of Fe2O3 NPs. The analysis of UV-Vis spectra indicates an absorption peak at 302 nm, thereby confirming both the successful synthesis and remarkable stability of the NPs. The NPs exhibited uniform spherical morphology and contained Fe, O, and N, indicating the synthesis of Fe2O3 NPs. Additionally, the Fe2O3 NPs formed through biosynthesis demonstrated antimicrobial capabilities against Escherichia coli and Bacillus cereus. The significant anti-migratory potential on MDA-MB 231 human breast cancer cells was observed with lower concentrations of the biosynthesized Fe2O3 NPs, and higher concentrations revealed cytotoxic effects on the cells with an IC50 of 95.7 μg/ml. Stable Fe2O3 NPs were synthesized using M. piperita aqueous extract, and it revealed antimicrobial activity on E. coli and B. cereus, cytotoxic, anti-proliferative and anti-migratory effect on highly metastatic human breast cancer cell lines.

Published on: December 05, 2023
doi: 10.17756/nwj.2023-127
Citation: Umar H, Aliyu MR, Ozsahin DU. 2023. Iron Oxide Nanoparticles Synthesized Using Mentha piperita Extract and Evaluation of Its Antibacterial and Antimigratory Potential on Highly Metastatic Human Breast Cells. NanoWorld J 9(4): 144-151.

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