The machining performance is compared when using copper oxide (CuO) nanofluid and conventional coolant for flood cooling while machining Inconel 718 material in computer numerical control (CNC) turning operation is focused in this research. CNC turning of Inconel 718 is performed with several parameter settings, and the resulting data is used to determine the material removal rate (MRR). Flood coolant of CuO nanofluid was used to machine at varying inputs of speed, tool feed, and depth of cut. Group 1 consisted of samples machined using nanofluid, while group 2 consisted of samples machined using conventional coolant. Each group consists of 16 samples and a total sample size of 32. Pre-1test G-power used was 80%. Both groups are compared for finding the best coolant to improve the MRR. The MRR of the CuO nanofluid (group 1) was 1032.710 mm³/min, whereas the mean MRR of Inconel 718 using conventional coolant (group 2) was 795 mm³/min. The significance value (p) obtained for the results was 0.0199 and it is less than 0.05, the observations are statistically significant between groups. After conducting an experimental study, CuO nanofluid supported well for machining and improve the MRR significantly.

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