Abstract
Solid lipid nano formulation is an interesting approach to increase poorly soluble drugs bioavailability. Naftidrofuryl (class IV drug) is a serotonin antagonist that belongs to the class of vasodilators and has only 10% bioavailability due to its low solubility and permeability. The current work deals with the nano formulation of naftidrofuryl solid lipids by microemulsion method. The solid lipid nano formulation was characterized by particle size (PS), zeta potential (ZP), and transmission electron microscope (TEM) analysis. The results showed that the PS was 82.1 nm with a ZP of -56.6 mV, showing good stability. TEM analysis shows that the particles had spherical solid lipid morphology. The analytical method was developed and validated as per the ‘(Q2) R1 ICH’ guidelines. All the results reported were in specified limits. Forced degradation studies of naftidrofuryl were conducted according to International Conference on Harmonization (ICH) (Q1A) R2 guidelines.
doi: 10.17756/nwj.2023-s3-097
Citation: Maruboyana LP, Naanabala P, Ramaswamy S, Gade R, Dwarampudi LP, et al. 2023. Strategic Improvement of the Solubility and Permeability of Naftidrofuryl Through Novel Solid Lipid Nano Formulation Technology and Method Development and Validation Using the RP-HPLC Method. NanoWorld J 9(S3): S536-S543.
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