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  Scopus ID: 21100926589

Characterization, Synthesis, and Evaluation of Antimicrobial, Anticancer Properties of Laurus nobilis-derived ZnO Nanoparticles

Doga Kavaz
 

Abstract

The application of nanotechnology is a relatively emerging area of study that has only recently proven its role as a key aspect of modern materials science. Green synthesizing nanoparticles by employing extracts from plants are very remarkable owing to their being cheap, ecologically sustainable, and can be produced on a large scale. Synthesis of ZnO NPs, or zinc oxide nanoparticles is the subject of this current study, by utilizing extracts from bay leaves, as well as their characterization and biological properties, with the aim of discovering prospective applications in the field of biomedicine. The Laurus nobilis leaf concentrate was employed in the production of ZnO NPs. The ZnO NPs that were produced were described using UV-Visible spectroscopy, DLS (Dynamic Light Scattering), SEM (Scanning Electron Microscope), XRD (X-ray Diffraction), and FT-IR (Fourier Transform Infrared Spectroscopy). The ZnO NPs were found to have a consistent distribution of spherical particles without any discernible aggregation, according to the SEM analysis. Investigation showed that synthesized ZnO NPs exhibit a Wurtzite hexagonal configuration having a median size of particles of 68.8 nm. Antibacterial studies have demonstrated that ZnO NPs are useful against a wide variety of bacteria, including Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922). Disc diffusion assay results revealed that S. aureus showed 19.5 ± 0.75 mm and E. coli showed 12.5 ± 0.68 mm diameter zone of bacterial growth inhibition. Using in vitro MTT assay, the antiproliferative properties of ZnO NPs were investigated in human breast cancer cell line. The findings show that the synthesized ZnO NPs demonstrated antiproliferative properties depending on the dose at the tested period of incubation and concentrations.

Published on:  July 19, 2023
doi: 10.17756/nwj.2023-117
Citation: Kavaz D. 2023. Characterization, Synthesis, and Evaluation of Antimicrobial, Anticancer Properties of Laurus nobilis-derived ZnO Nanoparticles. NanoWorld J 9(3): 55-61.

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