The aim of this study is to develop a novel cutaneous delivery technology that can create micro-sized channels to transport nanospheres within the top layer of skin for localized and systematic nanoparticulate therapeutics delivery using microneedle device, to produce sustained release and produce a localized effect which will lead to effective treatment of a variety of life-threating dermatological conditions. The skin is a natural barrier against particle permeation for topical delivery. However, it also offers a potential approach for delivery through transdermal route using microneedle. Capsaicin loaded PLGA nanoparticles may be useful in reduction of localized pain and itch associated with various ailments and treating dermatological diseases.

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