Metal nanoparticles has obtained considerable attention in cancer therapeutics in addition to their role in food packaging, sensors, drug delivery, cell labelling, medical dressings etc. Among those silver nanoparticles (SNPs) has been extensively synthesized to identify their role in antimicrobial, disinfectant, antitumor activities comparative to other metal- NPs. Owing to the simple, bio-compatible, and cost-effective nature, biogenic methods are preferred rather than physical or chemical ways for the fabrication of SNPs. In past times wide scientific research through metal-NPs has been conducted to investigate the nano-mechanics behind the cytotoxic behavior in cancer therapeutics. Based on the thorough literature survey it has been noted that nanoparticles induce cellular toxicity by stimulating various cellular factors (i.e., enzymatic leakage, oxidative stress generation, DNA damage, cell-cycle regulation etc.). In current article, an insight into the recent updates considering the potential development & nano-mechanics of plant-based SNPs has been presented.

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