Polyfunctionalized tetrahydro-benzopyrans known as important oxygencontaining privileged heterocyclic scaffolds offers wide range of useful applications in medicinal chemistry, biochemistry, and pharmacology. Owing to its pronounced pharmacological and biological applications, a wide range of catalysts including homogeneous and heterogeneous have been explored for efficient and environmental benign synthesis of polyfunctionalized tetrahydrobenzopyranes. Among the various types of catalyst, nanomaterials-based catalyst seems to be an exceptionally effective catalysts for various types of organic transformations as they offer advantages like large surface area-to-volume, broad functional group tolerance, milder reaction conditions, high yields, reusability, recyclability, simple and easy fabrications etc. In this review, we have described an overview of different nanomaterial-based catalysts for environmental benign synthesis of polyfunctionalized tetrahydro-benzopyrans. In this article, we provide special emphasis on functionalized magnetic nano catalysts and composite based nanomaterials for synthesis of tetrahydro-benzopyrans and derivatives. Additionally, we have described design, fabrication, and characterization of interesting nanomaterials along with their reaction mechanism for synthesis of tetrahydro-benzopyrans heterocyclic scaffolds.

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