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HTIB and PhICl2 Hypervalent Iodine Reagents: Versatile and Prominent Reagents in Synthetic Chemistry

Satya Prakash Choudhary, Rakshanda Singhal, Babita Gupta and Meenakshi Pilania


Hypervalent iodine reagents are versatile, realistic, and ubiquitously used in organic and inorganic chemistry. Hypervalent iodine reagents have been used since the early twenty century by chemists and in this long time a large plethora of hypervalent iodine reagents have been designed by researchers. Well-known hypervalent reagents hydroxyl(tosyloxy)iodobenzene (HTIB) and iodobenzene dichloride PhICl2 have advantageous characteristics of innocuous, environmental-friendly, economical, readily available, high stability, and easy to handle, which make it highly applicable in synthesis chemistry. Iodine is present in a +3-oxidation state in these hypervalent iodine reagents, this oxidation state makes iodine a strong electrophile. Higher electrophilic nature combined with good leaving groups makes hypervalent iodine an epicenter of nucleophilic attacks and nucleophilic attacks are the pivotal step in the chemistry of these hypervalent iodine reagents. These hypervalent iodine reagents being highly pragmatic synthons play their role perfectly in general oxidation to selectively oxidation, halogenation, arylation, hetero-arylation, aminations, rearrangement, cyclization, carbon-carbon, carbon-hetero bond-forming, and alkylation. HTIB and PhICl2 are easy to convert into other hypervalent iodine reagents.

Published on: November 08, 2022
doi: 10.17756/nwj.2022-s1-028
Citation: Choudhary SP, Singhal R, Gupta B, Pilania M. 2022. HTIB and PhICl2 Hypervalent Iodine Reagents: Versatile and Prominent Reagents in Synthetic Chemistry. NanoWorld J 8(S1): S176-S184.

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