With the aim to discover molecules which can treat different diseases in the nanomolar scale, various researchers are investigating the properties of transition metal complexes of Schiff base ligands. These ligands are versatile ones, containing an azomethine group (-CH=N-). They behave as good ancillary ligands since they can be easily synthesized by condensation reaction between primary amines and carbonyl derivative and can form transition metal complexes easily. These complexes have exhibited huge potential in medicinal and pharmaceutical fields as they show a broad range of biological activities. Among these activities, antibacterial as well as antifungal activities were found to be quite prominent. Various research groups have explored the interactions of different transition metal complexes of Schiff base ligands with both Gram-positive and Gramnegative bacteria as well as with various strains of fungi. Herein, a brief overview of the syntheses and biological activities of different Schiff base ligands along with their palladium, cobalt and copper complexes is presented.

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