Volume 3, Special Issue 2

Special Issue on Regenerative Medicine: Unfolding the Nanoworld of Stem Cells towards a Self-Healing Potential – Introduction

Carlo Ventura
Progress in understanding stem cell biology is holding promise for a novel perspective in the cure of diseases that cannot be currently approached even by the most advanced pharmacological or surgical interventions. The emerging chance for a Regenerative Medicine tailored on patient-specific unmet clinical needs may prelude to the unprecedented opportunity for a Precision Medicine.

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Regulation of the Adaptive Response of Cardiac Cells to Ischemia: Role of Nanovesicles

Gaia Papini and Vincenzo Lionetti
Ischemic heart disease represents 1 in 4 of total global deaths worldwide. Myocardial intercellular cross-talk regulate simultaneously the tissue homeostasis between neighboring cardiac cells in response to acute or chronic ischemic insult. Different studies have suggested that the heterocellular communication of adult myocardium is mainly based on the release of several free soluble biofactors into the extracellular milieu and on the spreading of different ions through selective channels.

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Nanotechnology Advances in Drug Delivery

Diana Velluto and Camillo Ricordi
Drug delivery emerged as a discipline to solve problems associated with the majority of the current drugs, such as poor water solubility, poor physical stability, poor absorption and side effects. Large pharmaceutical companies are investing in drug delivery technologies to find better ways to administer existing drugs rather than designing new products.

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Seeing Cell Biology with the Eyes of Physics

Carlo Ventura
Rhythmic oscillatory patterns permeate the entire universe and sustain cellular dynamics at biological level. The intracellular environment is now regarded as a complex nanotopography embedding “intracrine” signals that encompass the intracellular action of regulatory molecules coupled with the newly discovered functions of the microtubuar network.

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