Volume 3, Special Issue 1

Protein Confinement in the Anodic Porous Alumina Microarray

Claudio Larosa, Stefano Fiordoro, Claudio Nicolini and Eugenia Pechkova
Alternative approaches to solve the complexity of protein function in the proteomic field required new arrays in nano-micro-scale dimension. Anodic Porous Alumina (APA), a geometrically ordered inorganic oxide, grown from ultrapure aluminum by anodic oxidation, was used in this work as an ordered array for the confinement of protein molecules by spin-coating technique.

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Stability and Radiation Damage of Protein Crystals as Studied by Means of Molecular Dynamics and Monte Carlo Simulation

Philipp S. Orekhov, Marine E. Bozdaganyan, Eugenia Pechkova and Claudio Nicolini
Molecular Dynamics (MD) and Monte Carlo (MC) simulations of crystals can help in interpretation of experimental X-ray crystallography data. Particularly, they can be useful for understanding how various crystallization techniques affect protein conformational plasticity within the crystal lattice and the stability of biomolecular…

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Special Issue on Protein Nanotechnology for Biophysical and Biomedical Studies – Introduction

Eugenia Pechkova
In the post-genomic era, the structural and functional proteomics come to the forefront and this requires novel approaches for the fast and successful proteins characterization. Advanced biophysical studies are required in order to understand protein-protein interaction, lying at the base of our understanding of all life processes and of major challenges of the century – cancer and degenerative diseases.

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