Volume 1, Issue 1

Nanoprobe NAPPA Arrays for the Nanoconductimetric Analysis of Ultra-Low-Volume Protein Samples Using Piezoelectric Liquid Dispensing Technology

Eugenia Pechkova, Wiktor Peter, Nicola Bragazzi, Festa Fernanda and Claudio Nicolini
In the last years, the evolution and the advances of the nanobiotechnologies applied to the systematic study of proteins, namely proteomics, both structural and functional, and specifically the development of more sophisticated and largescale protein arrays, have enabled scientists to investigate protein interactions and functions with an unforeseeable precision and wealth of details.

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NAPPA-Based Vaccines for a New Proteogenomics Approach for Public Health

Nicola Luigi Bragazzi, Eugenia Pechkova and Claudio Nicolini
Vaccinology was developed for the first time in 1796 when Jenner empirically implemented a vaccine against smallpox using animal-to-human cowpox inoculation. Since then, it has become a very complex science due to the merging of disciplines ranging from structural and functional, cellular and molecular biology and immunology to bioinformatics and nanobiotechnology, as well as systems biology and synthetic biology and engineering.

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Synchrotron Diffraction of Multilayered LS PGA Films after Heating and Cooling

Claudio Nicolini, Wright John and Eugenia Pechkova
X-ray diffraction patterns of multilayered Langmuir-Schaefer (LS) film of penicillin G acylase (PGA) enzyme were acquired at the ID11 of Synchrotron Radiation at ESRF (Grenoble, France). In addition to what shown by GISAXS at ID13 and by AFM, the ID11 beamline appears capable to monitor the diffraction and structural properties of the Langmuir-Shaefer multilayered PGA enzyme film similar to what apparent in the corresponding PGA crystals.

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A New Journal for a New Useful Science and a Just World

Claudio Nicolini
The warning for humanity was never so serious from his origin and the overall world priority has to be rewritten centering the emphasis on the immediate solution of the dramatic problems facing humanity in energy, health, environment and worldwide exploding conflicts.

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